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Overview of applications in medicine and physiology

Results of the research PhA program provide new opportunities for solving various problems of research and applied. This review presents the main directions of development of the research program in the field of practical medicine, physiology and medical engineering.

Medical Engineering

The presence of efficient algorithms and software tools allow you to implement parametric identification in silico device adaptive control elements of cardiopulmonary bypass and circulatory support until completely artificial heart. Thus, it should be noted that the possibility of "individualization" model will make these devices take into account the maximum physiological characteristics of an individual patient.

As an example, consider the practical application of the model intra-aortic counterpulsation (KPIA). KPIA is by circulatory support, which aims to reducing the load on the heart in acute heart failure. The essence of the method consists in the introduction into the aorta bladder that can expand and contract under of an external air pump managed.

Physiology and medical sciences

In medical research and pharmacology PhA research programs provides a powerful tool of computer simulation of classical statistical medical experiment. The methodology of the application of this tool is tested on the example of a factor analysis the causes of hypertension.применения этого инструмента опробована на примере факторного анализа причин возникновения артериальной гипертензии.

Practical medicine

Implementation of the PhA research program also provides new unique means of indirect measurements, when the value is not available for direct measurement of the parameters measured by measuring certain other parameters of the organism. The task of finding non-invasive and minimally invasive methods to assess with reasonable accuracy for many physiological parameters that are inaccessible to direct measurement, remains relevant to everyday clinical practice. Parameter identification of physiological systems provides fairly universal method for using a single computational algorithm to obtain such estimates based on limited set of clinically available measurements.

PhA Technology used to estimate the important physiological parameter circulating blood volume (CBV). No there is a simple, accurate and inexpensive method of measuring the CBV. Invited a large number of techniques that can be divided into dilutional requiring the introduction into the bloodstream of different indicators (dyes, radioactive labels, etc.) and practically nedilyutsionnye more preferred that administration indicators do not require. Clinical evaluation of the CBV to date mainly carried out on a number of formulas and nomograms are difficult reproducible, costly and in clinical practice is not yet widely used. PhA is the basis of a new method of measuring nedilyutsionnogo CBV, which is based on the idea of objectification interdependence bcc physiological variables of the body, primarily with hemodynamics and blood composition.

Recommended references

A. P. Proshin and Yu. V. Solodyannikov. Mathematical Modeling of Blood Circulation System and Its Practical Applications // Automation and Remote Control, Vol. 67, No. 2, 2006, pp. 329-341.

The human blood circulation system is represented by a nonlinear oscillation system for computer-aided digital modeling in real time scale. A parametric identification problem is formulated and its numerical solution algorithm is designed. A computer-aided blood circulation modeling and identification system is designed. The new approaches to construct real control systems for artificial and auxiliary blood circulation elements are based on neurocomputer technologies.

A. P. Proshin and Yu. V. Solodyannikov. Identification of the parameters of blood circulation system // Automation and Remote Control, Vol. 71, No. 8, 2010, pp. 1629-1647.

A formulation of the problem of parametric identification from measurements of periodic motion was considered using a mathematical model of the blood circulation system. A method for its numerical solution on the basis of the random global search algorithm was proposed. A software realization of the identification procedure as parallel computation processes in the symmetrical multiprocessor computer systems and the distributed computation environment was described. Practical applications were considered using the example of factor analysis of the origins of arterial hypertension and also medical and sport applications, including the noninvasive monitoring of the level of blood hemoglobin and some kinds of stimulants.

A. P. Proshin and Yu. V. Solodyannikov. Mathematical modeling of lactate metabolism with applications to sports // Automation and Remote Control, Vol. 74, No. 6, 2013, pp. 1004-1019.

Based on a mathematical model of the blood circulatory system, we construct a mathematical model for lactate metabolism in a human body. We pose the identification problem for lactate metabolism parameters by measurements. We develop the method, algorithm, and software for solving this identification problem. We also consider practical applications in sports medicine and the training process, in particular in our studies of the anaerobic threshold phenomenon and propose new methods for estimating the individual anaerobic threshold and maximal oxygen consumption for athletes.


The article presents a method of mathematical modeling and identification of parameters of the circulatory system for the measurement of the absolute value of circulating volume blood.